发明名称 |
Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens |
摘要 |
An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
|
申请公布号 |
US2007026022(A1) |
申请公布日期 |
2007.02.01 |
申请号 |
US20060436757 |
申请日期 |
2006.05.19 |
申请人 |
DADAGLIO GILLES;LECLERC CLAUDE;LADANT DANIEL;EYNDE BENOIT V D;MOREL SANDRA;BAUCHE CECILE |
发明人 |
DADAGLIO GILLES;LECLERC CLAUDE;LADANT DANIEL;EYNDE BENOIT V.D.;MOREL SANDRA;BAUCHE CECILE |
分类号 |
A61K39/10;C07H21/04;C07K14/235;C12N1/21;C12N15/74 |
主分类号 |
A61K39/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|