Novel curcumin analogues and uses thereof

摘要

Disclosed is a compound according to formula I wherein: R1 and R2 are each independently selected from the group consisting of alkoxy, nitro, amino, and dialkylamino; R3 and R4 are each independently selected from the group consisting of hydroxy, alkoxy, and -OR7C(O)R8 wherein R7 is lower alkylene and R8 is alkoxy; or R1 and R3 together are alkylenedioxy; or R2 and R4 together are alkylenedioxy; R5 and R6 are each independently selected from the group consisting of H, halogen, and nitro; X1 is N, or X is C bonded to a H, alkoxy or nitro; and X2 is N, or X is C bonded to a H, alkoxy or nitro. Compounds of the type disclosed are androgen receptor agonists and are useful in the treatment of cancer.