STABLE CONTROLLED-RELEASE PELLET CONTAINING TOLTERODINE

摘要

Provided is a novel pharmaceutical composition which is capable of improving the stability over time of a drug pellet during storage and distribution of the pellet having controlled release properties. More specifically, the present invention provides a novel pharmaceutical composition which is capable of preventing moisture-induced changes in a drug release rate during storage and distribution of a drug pellet, via coating of a controlled-release pellet, particularly sustained-release pellet, comprising tolterodine, a tolterodine compound or a pharmaceutically acceptable salt thereof as a drug, with a dimethylaminoethyl methacrylate/methyl methacrylate copolymer (hereinafter, referred to as "Eudragit E") or polyvinylacetal diethylaminoacetate (hereinafter, referred to as "AEA") which is insoluble at a pH of 5.5 or higher.