A process for producing N-carboxyanhydrides is disclosed. The process produces N-carboxyanhydrides as a product and HCl as a by-product. The HCl by-product is purged from the reaction mixture by passing a purge gas through the reaction mixture as a carbonylation reagent is reacting with an amino acid or a salt thereof. The N-carboxyanhydrides produced by this process have a relatively lower chloride impurity content, relatively higher yields can be achieved, and the N-carboxyanhydrides can be produced on a larger scale.
申请公布号
WO2006047703(A3)
申请公布日期
2007.01.25
申请号
WO2005US38836
申请日期
2005.10.26
申请人
SIGMA-ALDRICH CO.;CARUBIA, JOHN MICHAEL;WEAVER, THOMAS MARK;PONNUSAMY, ETTIGOUNDER
发明人
CARUBIA, JOHN MICHAEL;WEAVER, THOMAS MARK;PONNUSAMY, ETTIGOUNDER