DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS

摘要

The invention relates to a compound having general formula (I), wherein: A is selected from among one or more X, Y and/or Z groups; X represents an optionally-substituted methylene group; Y represents a C2-alkenylene, optionally substituted, or a C2-alkynylene; Z represents a C3-7 cycloalkyl group; n represents an integer varying between 1 and 7; R1 represents an optionally-substituted heteroaryl or naphthalenyl type group; and R7 represents a hydrogen atom or a C1-6 alkyl group; R8 represents a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C3-7cycloalkyl-C1-3 alkylene group. The inventive compound takes the form of a base, an acid addition salt, a hydrate or a solvate. Said compounds have an inhibitory activity on the FAAH enzyme. ® KIPO & WIPO 2007