AQUEOUS PROCESS FOR MANUFACTURING PAROXETINE SOLID DISPERSIONS

摘要

A process for preparing solid, amorphous paroxetine comprising: (A) mixing paroxetine free base or a pharmaceutically acceptable paroxetine salt with water and pharmaceutically acceptable polymer; and (B) drying to form a composition comprising amorphous paroxetine and polymer, eliminating the need for organic solvents common for the solven t process. The resultant amorphous solid paroxetine composition is free from the crystalline form, and yet has good handling properties, making it suitable for pharmaceutical use in the traditional tablet dosage form.