Azole compound and medicinal use thereof

摘要

The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is -COOR⁷, -X¹-A¹-COOR⁷ (R⁷ is H, alkyl) or tetrazolyl; R¹, R², R³ and R⁴ are H and the like; A is -(CH₂)_m-X- (X is -N(R⁸)-, -C(R⁹)(R¹⁰)-, -CO- or -CO-N(R⁸)-); B is aryl or aromatic heterocyclic group; R⁵ is H and the like; R⁶ is -(Y)_s1-(A²)_s-Z (Y is -O-, -S(O)_t-, -N(R¹³)-, -N(R¹⁴)-CO-, -N(R¹⁴)-SO₂-, -SO₂-N(R¹⁴)- and the like, A² is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.