摘要 |
<p>The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.</p> |
申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
SALAGNAD, CHRISTOPHE;ZOCHER, FRANK;BURGARD, ANDREAS;JUNKER, BERND;HOERLEIN, ROLF-LUDWIG;STUEDEMANN, THOMAS;MAIER, CLAUS-JUERGEN;HACHTEL, JOCHEN;HOLLA, WOLFGANG;TAPPERTZHOFEN, CHRISTOPH;KULITZSCHER, BERNDT;MUTTI, STEPHANE |