METHODS OF MODULATING SMYD3 FOR TREATMENT OF CANCER
摘要
The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified.
申请公布号
WO2007004526(A2)
申请公布日期
2007.01.11
申请号
WO2006JP313038
申请日期
2006.06.23
申请人
ONCOTHERAPY SCIENCE, INC.;THE UNIVERSITY OF TOKYO;NAKAMURA, YUSUKE;FURUKAWA, YOICHI;HAMAMOTO, RYUJI;NAKATSURU, SHUICHI