CORE 2 GLCNAC-T INHIBITORS III

摘要

Treatments for conditions involving detrimental activity of the enzyme core 2 GIcNAc - T are provided using compounds of the formula (I) wherein R¹ is H, -OH, C_1-6 alkoxy, -NR⁵R₆, or Sac 1; R²is H, -OH, C_1-6 alkoxy or Sac 2; R ³ is H, -OH, C_1-6 alkoxy or Sac 3; R⁴ is H, C_1-6 alkyl, C_1-6 hydroxyalkyl or C_1-6-alkoxy- C_1-6 -alkyl; R⁵ is H, C_1-6 alkyl or C_1-6 acyl; R⁶ is H, C_1-6 alkyl or C_1-6 acyl; Sac 1 Sac 2 and Sac 3 are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester form thereof