发明名称 |
Boat tropanes |
摘要 |
Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
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申请公布号 |
US2007009432(A1) |
申请公布日期 |
2007.01.11 |
申请号 |
US20060517676 |
申请日期 |
2006.09.08 |
申请人 |
GENERAL HOSPITAL CORPORATION, THE |
发明人 |
MELTZER PETER C.;BLUNDELL PAUL;MADRAS BERTHA K.;FISCHMAN ALAN J.;JONES ALUN G.;MAHMOOD ASHFAQ |
分类号 |
A61K51/00;C07D451/02;A61K31/46;A61K51/04;A61P25/00;A61P25/28;A61P43/00;C07F13/00 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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