发明名称 |
BONE DENSIFYING AGENT CHARACTERIZED BY USE OF CATHEPSIN K INHIBITOR WITH PTH |
摘要 |
<p>The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.</p> |
申请公布号 |
EP1741441(A1) |
申请公布日期 |
2007.01.10 |
申请号 |
EP20050734608 |
申请日期 |
2005.04.25 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
OCHI, YASUO;TANAKA, MAKOTO;KAWADA, NAOKI;YAMADA, HIROYUKI;MORI, HIROSHI;KAYASUGA, RYOUJI |
分类号 |
A61K31/427;A61K38/22;A61K31/4015;A61K31/426;A61K38/29;A61K45/00;A61K45/06;A61P1/02;A61P3/14;A61P19/02;A61P19/08;A61P19/10;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C07D417/12 |
主分类号 |
A61K31/427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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