MOLECULAR DIVERSITY TECHNOLOGY OF PYRAZOLE LIBRARY BASED ON COMBINATORIAL CHEMISTRY

摘要

A molecular diversity technology of pyrazole derivatives based on combinatorial chemistry is provided to enable a user to easily test biological activity with respect to disease target and manufacture a high purity of target compound with high yield more easily and rapidly than a classical synthetic method. The molecular diversity technology of pyrazole derivatives based on combinatorial chemistry manufactures pyrazole derivatives having a structure of the formula(1) by composing pyrazole derivative compound by performing cyclization by reacting R1COCH2CN compound with R2NHNH2ÀHCl compound firstly and using solution state reaction of R3C6H5NCO compound with the composed compound. In formula(1), X and Z are NH, Y is O and S, and R1, R2, R3 are H, alkyl group of C1-C8 or cyclo alkyl group of C3-C6, phenyl alkyl group of C1-C8, hydroxy alkyl group of C1-C8, and aromatic compound alkyl group of C3-C8.