USE OF MODIFIED TALL-104 CELLS TO TREAT CANCER AND VIRAL DISEASES

摘要

The invention provides a modified human cytotoxic T cell line, which is characterized by dual activity in vitro and in vivo against tumor cells and virus-infected cells. Also provided are effective and safe methods for use o f the modified cells in adoptive therapy of cancer and untreatable viral diseases in MHC-mismatched recipients, and in marrow purging to achieve complete eradication of residual tumor cells from marrows of patients with leukemia and other types of cancer. Also provided are effective and safe methods for use of the modified cells in the manufacture of a veterinary composition for adoptive therapy of canin e lymphoma and feline leukemias.