发明名称 |
COMPOSITION AND METHOD FOR INHIBITING PLATELET AGGREGATION |
摘要 |
This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutic effective amount of P2Y12 receptor antagonist compound, wherein said amount is effective to bind the P2Y12 receptors on platelets and inhibit ADP-induced platelet aggregation. The P2Y12 receptor antagonist compounds useful for this invention include mononucleoside 5'-monophosphates, mononucleoside polyphosphates, and dinucleoside polyphosphates of general Formula I, or salts thereof. The present invention also provides novel compounds of mononucleoside 5'- monophosphates and dinucleoside diphosphates. The present invention further provides pharmaceutical formulations comprising a pharmaceutical carrier and mononucleoside 5'-monophosphates or dinucleoside diphosphates. ® KIPO & WIPO 2007
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申请公布号 |
KR20070003993(A) |
申请公布日期 |
2007.01.05 |
申请号 |
KR20067020238 |
申请日期 |
2006.09.28 |
申请人 |
INSPIRE PHARMACEUTICALS, INC.;UNIVERSITY OF NORTH CAROLINA |
发明人 |
BOYER JOSE;DOUGLASS JAMES G. III;SHAVER SAMMY RAY;WATSON PAUL S.;KRISHNAMOORTHY RAMESH |
分类号 |
C07H19/20;A61K31/7072;A61K31/708;A61K31/7084;A61K38/43;A61K45/00;A61P7/00;A61P7/02;A61P7/08;A61P7/12;A61P9/00;A61P9/04;A61P9/10;A61P9/14;A61P13/00;A61P13/12;A61P15/00;A61P15/06;A61P17/02;A61P19/04;A61P25/06;A61P29/00;A61P31/04;A61P37/00;A61P39/00;A61P41/00;A61P43/00;C07F9/6561;C07H19/04;C07H19/10;C07H19/207;C07H21/00;C07H21/02;C07H21/04 |
主分类号 |
C07H19/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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