发明名称 Method of stabilizing lipid-rich plaque and method of preventing rupture thereof
摘要 A method of stabilizing lipid-rich plaques and method of preventing the rupture thereof, characterized in that an effective amount of 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4 -bis(methylthio)-6-methyl-3-pyridyl]acetamide, its acid adduct salt or a hydrate thereof is administered to patients with lipid-rich plaques. Prevention of plaque rupture and stabilization of plaques can be attained by reducing the occupancy of macrophages in lipid-rich plaques being unstable and tending to rupture among plaques being a lesion from a seat of atherosclerosis and simultaneously increasing the occupancy of collagen therein.
申请公布号 US2007004749(A1) 申请公布日期 2007.01.04
申请号 US20060569642 申请日期 2006.02.27
申请人 KOWA CO., LTD. 发明人 SHIBUYA KIMIYUKI;KOBAYASHI HIDEYUKI;YOSHINAKA YASUNOBU
分类号 A61K31/496;A61K31/4439;A61P9/10;C07D401/12 主分类号 A61K31/496
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