PEPTIDE CONJUGATE COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE

摘要

The invention provides compositions and methods for the treatment of diseases associated with amyloid deposits of Aß in the brain of a patient, such as Alzheimer's disease. Such methods entail administering an immunogenic fragment of Aß, lacking a T-cell epitope, capable of inducing a beneficial immune response in the form of antibodies to Aß. In another aspect, the immunogenic fragment of Aß is capable of elevating plasma Aß levels. The immunogenic fragments comprise linear or multivalent peptides of Aß. Pharmaceutical compositions comprise the immunogenic fragment chemically linked to a carrier molecule which may be administered with an adjuvant.