BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, ß-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER

摘要

It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the proliferation of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a carcinogenesis-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a carcinogenesis-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and carcinogenesis-preventive activity can be synthesized.