MURINE STEM CELLS AND APPLICATIONS THEREOF

摘要

The invention relates to animal solid tumour models which comprise a transgenic non-human mammal containing in its genome a DNA construct that comprises a gene created and/or activated by a genetic anomaly associated wi th human cancer operatively bound to a promoter that directs the expression of the gene in Scal+ cells. The invention also relates to stem cells capable of specifically expressing in stem cells human genetic anomalies associated wit h human pathologies. Applications of these models and stem cells, such as diagnostic, therapeutic and prophylactic applications for human diseases, an d products and methods are provided.