| 摘要 |
A method of inducing either a T<SUB>H</SUB>1 polarised immune response, a T<SUB>H</SUB>2 polarised immune response or a combined T<SUB>H</SUB>1 and T<SUB>H</SUB>2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised T<SUB>H</SUB>1 response by parenteral administration of microparticles sized such that at least 50% of the microparticles are less than 5 mum, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised T<SUB>H</SUB>2 response by parenteral administration of nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B. pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.
|
