| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide new low-molecular compounds which have G-CSF-like activities and can substitute for G-CSF preparations. <P>SOLUTION: The present invention provides G-CSF-like agonists containing, as the active ingredient, benzyl alcohol derivatives represented by the general formula (1) (wherein R<SP>1</SP>is a hydrogen atom or a lower alkyl group; A is an oxygen atom, a sulfur atom or a single bond; X<SP>1</SP>is a hydrogen atom, a halogen atom, a hydroxy group, an optionally substituted amino group, a lower alkyl group or a lower alkoxy group which may have a substituent ; Y<SP>1</SP>is an optionally substituted phenyl, a heterocyclic group which may have a substituent or a substituted amino group; Z<SP>1</SP>is a hydrogen atom, a lower alkoxycarbonyl group, a carboxy group, a lower alkoxy group, a lower alkoxy-lower alkoxy group, a hydroxy group, an optionally substituted amino group, an optionally substituted carbamoyl group or optionally substituted phenyl group or the like; n is an integer of 1 to 16) or salts thereof. <P>COPYRIGHT: (C)2007,JPO&INPIT</p> |
