| 摘要 |
<p>A composition having an agent adapted to affect a multimeric protein by binding to a binding site thereof and thereby affecting an equilibrium of units, the multimeric protein has an assembly having a plurality of said units, each of the units has a first complementary surface and a second complementary surface and the first complementary surface of one unit is associated with the second complementary surface of another unit, provided that the assembly is at least one of different quaternary isoforms and on a condition that in the multimeric protein (1) a structure of each of the units determines a structure of the different quaternary isoforms, (2) the units are in the equilibrium and (3) the structure of the different quaternary isoforms influences a function of the multimeric protein, wherein said multimeric protein is Pseudomonas aeruginosa GDP-Mannose dehydrogenase, Bacillus subtilis HPr, kinase/phosphatase, mammalian CoA transferase, purine nucleoside phosphorylase, or peroxiredoxins.</p> |
