Methods and compositions for treating flaviviruses and pestiviruses

摘要

The present invention provides pharmaceutical compositions for the treatment of a flavivirus or pestivirus infection in a host, wherein the infection is not hepatitis C, comprising an antivirally effective amount of a 2'-C-branched nucleoside or a 2'-C-branched ribofuranosyl nucleoside or pharmaceutically acceptable salts or esters thereof, in combination with one or more other anti-flavivirus or pestivirus agent. The present invention further provides for the use of a 2'-C-branched nucleoside or a 2'-C-branched ribofuranosyl nucleoside or pharmaceutically acceptable salts or esters thereof, in the manufacture of a medicament for the treatment of a flavivirus or pestivirus infection in a host, wherein the infection is not hepatitis C.