3-[(2-{[4-(HEXYLOXYCARBONYLAMINO-IMINO-METHYL)-PHENYLAMINO]-MENTHYL}-1H-BENZIMIDAZOL-5-CARBONYL)-PYRIDINE-2-YL-AMINO]-PROPIONIX ACID ETHYL ESTER METHANE SULPHONATE AND USE THEREOF AS A MEDICAMENT

摘要

Ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenylaminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino)propionate methanesulfonate polymorph I (Ia), polymorph II (Ib) and hemihydrate (Ic), with melting points of 180+-3[deg]C, 190+-3[deg]C and 120+-5[deg]C respectively, are new. Independent claims are also included for the preparation of (Ia)-(Ic). ACTIVITY : Anticoagulant; Cerebroprotective; Vasotropic. No biological data is given. MECHANISM OF ACTION : Thrombin inhibitor.