Histone deacetylase inhibitors

摘要

Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R₁, R₂, R₃ and R₄ are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C_1-12 alkyl, C_2-12 aminoalkyl or C_2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R₃ and R₄ are not both hydrogen; R₅ is selected from the group consisting of a carbonyl, a substituted or unsubstituted C_1-3 alkyl, a substituted or unsubstituted -C_1-3 alkyl-C(O), a substituted or unsubstituted -C(O)-C_1-3 alkyl, and a substituted or unsubstituted -C(O)C(O)C_1-3 alkyl; M is a substituent capable of complexing with a protein metal ion; and L is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.