发明名称 PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS
摘要 (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between Rl and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the inker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NR2 R3 group and provided that the oxo group when present is located at a carbon atom a with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; Rl is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents.
申请公布号 KR20060130621(A) 申请公布日期 2006.12.19
申请号 KR20067014742 申请日期 2004.12.23
申请人 ASTEX THERAPEUTICS LIMITED;THE INSTITUTE OF CANCER RESEARCH;CANCER RESEARCH TECHNOLOGY LIMITED 发明人 BERDINI VALERIO;SAXTY GORDON;VERDONK MARINUS LEENDERT;WOODHEAD STEVEN JOHN;WYATT PAUL GRAHAM;BOYLE ROBERT GEORGE;SORE HANNAH FIONA;WALKER DAVID WINTER;COLLINS IAN;DOWNHAM ROBERT;CARR ROBIN ARTHUR ELLIS
分类号 C07D231/12;A61K31/415;C07D401/04;C07D401/10;C07D413/10 主分类号 C07D231/12
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