发明名称 |
Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin |
摘要 |
The key intermediate in any synthesis of Irinotecan is 7-ethyl-10-hydroxy-20(S)-camptothecin. A process for the efficient synthesis of this intermediate is demonstrated proceeding through readily available 20(S)-camptothecin. Various other tecan compounds may be made by use of corresponding 7-alkyl-10-hydroxy-20(S)-camptothecin intermediates.
|
申请公布号 |
US7151179(B2) |
申请公布日期 |
2006.12.19 |
申请号 |
US20040844225 |
申请日期 |
2004.05.12 |
申请人 |
SCINOPHARM TAIWAN, LTD. |
发明人 |
LIN CHIEN-HSING;CHEN YUNG-FA;CHEN KAU-MING |
分类号 |
C07D405/14;C07D491/22 |
主分类号 |
C07D405/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|