| 摘要 |
The present invention relates to a compound of the formula 1 wherein R<SUP>1</SUP>-R<SUP>4 </SUP>are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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