BURKHOLDERIA RHIZOXINA MICRO-ORGANISMS, NOVEL ENDOSYMBIONTS OF RHIZOPUS SP. AND METHOD FOR PRODUCING RHIZOXIN AND/OR RHIZOXIN DERIVATIVES USING SAID MICRO-ORGANISMS

摘要

The invention relates to a method for producing rhizoxin and derivatives of rhizoxin. The aim of the invention is to produce novel micro-organisms that synthesise rhizoxin or derivatives of rhizoxin, and to provide a method for producing rhizoxin or derivatives thereof, without the disadvantages of prior art and in a simpler manner with a higher yield. To this end, bacterial symbionts of Rhizopus sp., in the form of Burkholderia Rhizoxina DSM 17360 or other Burkholderia Rhizoxina strains, are isolated, cultivated and used for the fermentative production of rhizoxin and/or derivatives of rhizoxin in a submerged culture, and the rhizoxin and/or the derivatives thereof are subsequently isolated from the culture supernatant.