The invention relates to the design and synthesis of 3-arylidene-anabaseine compounds that exhibit enhanced selectivity toward alpha7 nicotinic receptors. The compounds are expected to be useful in treating a wide variety of conditions, including neurodegenerative conditions such as Alzheimer's Disease, neurodevelopmental diseases such as schizophrenia, and certain peripherally located inflammations mediated by macrophage infiltration.
申请公布号
WO2006133303(A1)
申请公布日期
2006.12.14
申请号
WO2006US22136
申请日期
2006.06.07
申请人
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;KEM, WILLIAM, R.;SOTI, FERENC