发明名称 |
METHOD AND DEVICE FOR EVALUATION OF PHARMACEUTICAL COMPOSITIONS |
摘要 |
A membrane-permeation test for evaluating pharmaceutical compositions is described. The method comprises the following steps: (1) providing a microporous membrane having a plurality of pores, the membrane having a feed side and a permeate side, wherein the feed side of the membrane is in fluid communication with the feed solution, and wherein the permeate side of the membrane is in fluid communication with a permeate solution; (2) administering a pharmaceutical composition to an aqueous solution to form a feed solution; and (3) measuring the concentration of drug in the permeate solution; wherein the feed side of the membrane is hydrophilic, and/or wherein the permeate solution comprises an organic fluid. |
申请公布号 |
EP1730516(A1) |
申请公布日期 |
2006.12.13 |
申请号 |
EP20050708772 |
申请日期 |
2005.03.18 |
申请人 |
PFIZER PRODUCTS INCORPORATED |
发明人 |
BABCOCK, WALTER CHRISTIAN;FRIESEN, DWAYNE THOMAS;MCCRAY, SCOTT BALDWIN |
分类号 |
G01N33/15;B01D61/24;B01D61/28;B01D67/00;B01L3/00 |
主分类号 |
G01N33/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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