| 摘要 |
FIELD: medicine, pharmacy. ^ SUBSTANCE: invention relates, in particular, to a solid pharmaceutical composition used in treatment and prophylaxis of osteoporosis. The composition comprises derivative of bis-phosphonic acid that involves carbohydrate alcohol-base nuclei, preferably, mannitol and uniformly distributed in a homogenous mixture of active component and filling agents. Also, invention discloses a process for preparing the composition described above. Invention eliminates the chemical instability problem of derivatives of bis-phosphonic acid that are ready for using in solid medicinal formulations and during the process for their preparing, good physical properties (strength) of the solid medicinal formulation. ^ EFFECT: improved and valuable medicinal and pharmaceutical properties of composition. ^ 12 cl, 2 tbl, 1 ex |
