CPG OLIGONUCLEOTIDE PRODRUGS, COMPOSITIONS THEREOF AND ASSOCIATED THERAPEUTIC METHODS
摘要
The present invention provides a CpG oligonucleotide prodrug that includes a thermolabile substituent on at least one nucleotide thereof. The present invention also provides compositions that include a carrier and a therapeutically effective amount of at least one CpG oligonucleotide prodrug. The present invention further provides therapeutic methods of using such thermolabile CpG oligonucleotide prodrugs and compositions thereof. The present invention further provides a method of inhibiting tetrad formation in a CpG oligonucleotide by functionalizing the CpG oligonucleotide with one or more thermolabile substituents.
申请公布号
WO2006065751(A3)
申请公布日期
2006.12.07
申请号
WO2005US44935
申请日期
2005.12.13
申请人
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;VERTHELYI, DANIELA;BEAUCAGE, SERGE, L.;GRAJKOWSKI, ANDRZEJ
发明人
VERTHELYI, DANIELA;BEAUCAGE, SERGE, L.;GRAJKOWSKI, ANDRZEJ