摘要 |
Ophthalmically acceptable compositions used in arresting the development of cataract, presbyopia, macular degeneration and other retinopathies, glaucoma, uveitis and various corneal disorders are disclosed. The compositions are also useful as a prophylactic treatment to prevent or delay development of age-related ocular disorders, which include cataracts, presbyopia, glaucoma and macular degeneration. The compositions comprise a pharmaceutically acceptable carrier or diluent and at least one compound having the formula where R<SUB>1</SUB> and R<SUB>2</SUB> are, independently, H or C<SUB>1</SUB> to C<SUB>3</SUB> alkyl ; R<SUB>3</SUB> and R<SUB>4</SUB> are, independently C<SUB>1</SUB> to C<SUB>3</SUB> alkyl; and where R<SUB>1</SUB> and R<SUB>2</SUB>, taken together, or R<SUB>3</SUB> and R<SUB>4</SUB>, taken together, or both may be cycloalkyl; R<SUB>5</SUB> is H, OH, or C<SUB>1</SUB> to C<SUB>6</SUB> alkyl ; R<SUB>6</SUB> is or C<SUB>1</SUB> to C<SUB>6</SUB> alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl ; R<SUB>7</SUB> is C<SUB>1</SUB> to C<SUB>6</SUB> alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl or where R<SUB>6</SUB> and R<SUB>7</SUB>, or R<SUB>5</SUB>, R<SUB>6</SUB> and R<SUB>7</SUB>, taken together, form a carbocycle or heterocycle having from 3 to 7 atoms in the ring. |
申请人 |
OTHERA PHARMACEUTICALS, INC.;MATIER, WILLIAM, L.;PATIL, GHANSHYAM |
发明人 |
MATIER, WILLIAM, L.;PATIL, GHANSHYAM |