| 摘要 |
The present disclosure provides a process for producing sucralose from a feed mixture of (a) sucralose-6-ester, such as 6-O-acyl-4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose, (b) salt including alkali metal or alkaline earth metal chloride, (c) water, and (d) other chlorinated sucrose by-products, in a reaction medium comprising a tertiary amide, wherein said process comprises deacylating, either before or after removal of the tertiary amide, the sucralose-6-ester under active cooling to produce an aqueous solution comprising sucralose, salt including alkali metal or alkaline earth metal chloride, and other chlorinated sucrose by-products. Additionally, the sucralose may be recovered from the aqueous solution, such as by extraction followed by crystallization or by extractive techniques alone.
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