摘要 |
<p>The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1):
[wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z 1 represents alkylene, X 2 represents oxygen atom, sulfur atom, SO 2 , NR 5 , CO, CONR 5 , NR 5 CO and the like, Y 1 , Y 2 and Y 3 represent independently a single bond or an alkylene group, X 1 represents oxygen atom, sulfur atom, NR 4 (R 4 is hydrogen atom or an alkyl group) or a single bond, R 2 represents a substituted or unsubstituted alkyl group, R 1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.</p> |
申请人 |
DAINIPPON SUMITOMO PHARMA CO., LTD.;ASTRAZENECA AB |
发明人 |
KURIMOTO, AYUMU;HASHIMOTO, KAZUKI;ISOBE, YOSHIAKI;BROUGH, STEPHEN;MILLICHIP, IAN;WADA, HIROKI;BONNERT, ROGER;MCINALLY, THOMAS |