摘要 |
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 3, 4 or 5; q is 0 or 1; t is 0 or 1; R<SUP>1</SUP> is alkyl having from 1 to 3 carbon atoms; R<SUP>2</SUP> is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; R<SUP>3</SUP> is hydrogen or -(CH<SUB>2</SUB>)<SUB>g</SUB>OH wherein g is 0, 1 or 2; R<SUP>4</SUP> is hydrogen, methyl or ethyl; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; or a pharmaceutically acceptable salt of the compound. |
申请人 |
WELLSTAT THERAPEUTICS CORPORATION;SHARMA, SHALINI;VON BORSTEL, REID, W. |
发明人 |
SHARMA, SHALINI;VON BORSTEL, REID, W. |