AGONISTIC ANTIBODIES THAT BIND TO THE TWEAK RECEPTOR FN14 AND THEREBY MODULATE ADIPOSITY-ASSOCIATED PHENOTYPES AS WELL AS THEIR USE IN THERAPY

摘要

The present invention relates to agonists of the receptor Fn14 as well as their use for activating the signal pathway of the receptor Fn14 for interfering and/or modulating the differentiation of adipocytes and for use in adiposity/obesity and/or metabolic syndrome. In particular, the invention relates to agonists, preferably antibodies that inhibit the differentiation of pre-adipocytes to mature adipocytes and/or the storage of lipid molecules in differentiating or mature adipocytes by receptor-mediated signal transduction.