发明名称 |
POLYPEPTIDES |
摘要 |
The present invention provides polypeptides having the property of binding to a given Class I pMHC CHARACTERISED IN THAT said polypeptide has a KD for the said given Class I pMHC of less than or equal to l.mu.M and/or has an off-rate (koff) for the said given Class I pMHC molecule of 2 S-1 or slower AND said polypeptide has at least a 45 % identity and/or 55 % similarity to SEQ ID NO: 7 AND said polypeptide inhibits CD8 binding to the given pMHC to a greater extent than the polypeptide SEQ ID NO: 3. Such polypeptides are useful, either alone or associated with a therapeutic agent, for the inhibition of cyto-toxic T cell (CTL) responses.
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申请公布号 |
CA2609447(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
CA20062609447 |
申请日期 |
2006.05.19 |
申请人 |
AVIDEX LTD |
发明人 |
JAKOBSEN, BENT KARSTEN;LI, YI;MOYSEY, RUTH KAREN |
分类号 |
C07K14/705;A61K38/17;A61P37/00 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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