ORAL DRUG COMPLIANCE MONITORING USING RADIO FREQUENCY IDENTIFICATION TAGS

摘要

A device useful for oral drug delivery device consisting of: (a) a capsule,
tablet or pill designed to disperse in the gastrointestinal system; (b) an
RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an
antenna; (c) an object selected from the group consisting of a magnet, a
ferromagnetic object, a ferrite object and an electromagnetic shielding object
positioned within, over or adjacent the antenna of the RFID tag to alter the
antenna characteristics of the RFID tag so that if the RFID tag is
interrogated before the capsule, tablet or pill disperses in the
gastrointestinal system, the response of the RFID tag is sufficiently altered
or attenuated to determine that the capsule, tablet or pill has not dispersed
in the gastrointestinal system and so that if the RFID tag is interrogated
after the capsule, tablet or pill has dispersed in the gastrointestinal
system, the object separates from the RFID tag so that the response of the
RFID tag is sufficiently detectable to determine that the capsule, tablet or
pill has dispersed in the gastrointestinal system. Alternatively, a switch can
be used to signal ingestion of the device, and change the response of the
device. In another embodiment, the instant invention is a device useful for
oral drug delivery, consisting of: (a) a capsule, tablet or pill designed to
disperse in the gastrointestinal system; (b) a first non-anti-collision RFID
tag positioned in the capsule; (c) a second non-anti-collision RFID tag
positioned in the capsule, so that if the RFID tags are interrogated by an
RFID reader before the capsule, tablet or pill disperses in the
gastrointestinal system, the response of the RFID tags collide and so that
after the dispersible material of the capsule has dispersed in the
gastrointestinal system thereby allowing the first and second non-anti-
collision tags to separate from each other, then the response of the RFID tags
is sufficiently different from each other to determine that the capsule has
dispersed in the gastrointestinal system.