发明名称 |
ANTIBODY CALICHEAMICIN CONJUGATES FOR PASSIVE TARGETING |
摘要 |
<p>Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.</p> |
申请公布号 |
EP1725264(A2) |
申请公布日期 |
2006.11.29 |
申请号 |
EP20050732491 |
申请日期 |
2005.03.15 |
申请人 |
WYETH |
发明人 |
BOGHAERT, ERWIN, RAYMOND, ARSENE;KHANDKE, KIRAN, MANOHAR;DAMLE, NITIN, KRISHNAJI |
分类号 |
A61K47/48;C07K16/30 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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