RNA-CONTAINING COMPOSITION

摘要

A composition for use for introducing RNA into the blood, which comprises a complex of a carrier and RNA, where the carrier comprises a polycationic compound having, as a side chain, a hydrophilic group bound to the polycationic compound in a comb-like configuration. The polycationic compound is preferably a poly(cationic amino acid). By using the composition, the excretion of RNA from the kidney can be inhibited, and the RNA retention can be improved. For example, the treatment of cancer can be effected by introducing siRNA having a therapeutic effect on cancer into the blood by utilizing the composition. Further, it is found that the retention of RNA in the blood can also be improved by administering the carrier and RNA separately. The carrier may be, for example, PLL-Dex represented by the formula 1 or PLL-PEG represented by the formula 2.