发明名称 |
Methods of reducing microbial resistance to drugs |
摘要 |
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
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申请公布号 |
US2006264517(A1) |
申请公布日期 |
2006.11.23 |
申请号 |
US20050260676 |
申请日期 |
2005.10.26 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
OETHINGER MARGARET;LEVY STUART B. |
分类号 |
A61K31/496;G01N33/50;A01N31/14;A61K31/00;A61K31/085;A61K31/4704;A61K45/06;A61P31/00;A61P31/04;A61P43/00;C12Q1/02;G01N33/15 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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