发明名称 |
Succinoylamino lactams as inhibitors of A-beta protein production |
摘要 |
This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Abeta-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta-amyloid production such as Alzheimer's disease and Down's Syndrome.
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申请公布号 |
US2006258638(A1) |
申请公布日期 |
2006.11.16 |
申请号 |
US20060492593 |
申请日期 |
2006.07.25 |
申请人 |
BRISTOL-MYERS SQUIBB PHARMA COMPANY |
发明人 |
OLSON RICHARD E.;MADUSKUIE THOMAS P.;THOMPSON LORIN A. |
分类号 |
A61K31/554;C07D243/12;A61K31/55;A61K31/551;A61K31/5513;A61K31/553;A61P25/00;A61P25/28;A61P43/00;C07D223/12;C07D223/16;C07D243/24;C07D401/06;C07D401/10;C07D403/10;C07D405/12 |
主分类号 |
A61K31/554 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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