| 摘要 |
<p>New nucleotide sequences (I), encoding the variable region of the alpha chain of human Y lymphocyte receptor, correspond to cDNA comprising sequences reproduced in the specification (11 for V alpha segments; 8 for Jalpha segments). Included are sequences differing by 1 or several nucleotides or their fragments. Also new are (1) peptides (II) encoded by (I), including functionally equiv. alleles and derivs.; (2) expression vectors contg. DNA encoding (II); (3) host cells transformed with such vectors; (4) antibodies (Ab), and their fragments directed against an antigenic determinant of (II), opt. labelled and/or attached to a therapeutic molecule; (5) hybridomas producing such Ab; (6) oligonucleotides (III) corresponding to variable regions of the alpha chain. Sequences for Valpha w24, w25, w26, w27, w29, 1, 2, 5, 7, 22 and 16 (variously 330-569bp) are reproduced. The Jalpha sequences contain 50-277bp. The most pref. peptide is encoded by bases 108-364 of the Valpha 16 segment.</p> |
