发明名称 |
SCREENING METHOD FOR ATTENUATING OR VIRULENCE DEFECTIVE MICROBIAL CELLS |
摘要 |
This invention relates to a novel method for the genome saturating identification of nucleic acid sequences which are essential for infectivity and/or intracellular survival and/or propagation in permissive eukaryotic host cells, in particular microbial sequences. Further, a method for the identification of attenuated microorganisms and novel antimicrobial compounds using the identified essential nucleic acids and proteins encoded thereby is provided. |
申请公布号 |
EP1407014(B1) |
申请公布日期 |
2006.11.15 |
申请号 |
EP20020743053 |
申请日期 |
2002.05.17 |
申请人 |
CREATOGEN AKTIENGESELLSCHAFT |
发明人 |
FREISSLER, ELKE;FUCHS, THILO, M.;NIESALLA, HEIDE, S.;APFEL, HEIKO |
分类号 |
C12N15/10;A61K31/711;A61K39/112;A61K39/395;C07K14/255;C07K16/12;C12N1/21;C12N15/31;C12N15/90;C12Q1/68;G01N33/68 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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