ROLE OF HUMAN KIS (HKIS) AS AN INHIBITORY KINASE OF THE CYCLIN-DEPENDENTKINASE INHIBITOR P27. COMPOSITIONS, METHODS AND USES THEREOF TO CONTROL CELL PROLIFERATION

摘要

Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.