| 摘要 |
The present invention relates to intercellular adhesion molecule-4 (ICAM-4), including binding sites on ICAM-4, antagonists affecting ICAM-4 and uses thereof. In one aspect of the invention there is provided an epitope for binding integrins, comprising strands A (or F) and G of domain 1 of ICAM-4. In another aspect of the invention there is provided a footprint domain for binding integrins, comprising a first epitope as defined above and second epitope comprising the C and F strands of domain 1 and the CE loop of domain 2 of ICAM-4.
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