发明名称 |
8A, 9-DIHYDRO-4A-H-ISOTHIAZOLO[5,4-B] QUINOLINE-3, 4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS |
摘要 |
The invention provides compounds and salts of Formula I and Formula II which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables n, m, p, RA, RB, A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and /or selective inhibitors of bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II an d one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in eukaryotes.
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申请公布号 |
CA2587485(A1) |
申请公布日期 |
2006.11.09 |
申请号 |
CA20052587485 |
申请日期 |
2005.11.10 |
申请人 |
ACHILLION PHARMACEUTICALS, INC. |
发明人 |
LUCIEN, EDLAINE;HASHIMOTO, AKIHIRO;SONG, YONGSHENG;PUCCI, MICHAEL JOHN;WANG, QIUPING;BRADBURY, BARTON JAMES;WILES, JASON ALLAN;DESHPANDE, MILIND |
分类号 |
C07D513/04;A61K31/437;A61P31/04;A61P33/02 |
主分类号 |
C07D513/04 |
代理机构 |
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