| 发明名称 |
Adenosine receptor antagonists and methods of making and using the same |
| 摘要 |
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A<SUB>1 </SUB>receptor. Adenosine A<SUB>1 </SUB>antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
|
| 申请公布号 |
US2006252730(A1) |
申请公布日期 |
2006.11.09 |
| 申请号 |
US20060484805 |
申请日期 |
2006.07.10 |
| 申请人 |
KIESMAN WILLIAM F;ENSINGER CAROL L;PETTER RUSSELL C;DOWLING JAMES E;KUMARAVEL GNANASAMBANDAM;CHANG HE XI;LIN KO CHUNG |
发明人 |
KIESMAN WILLIAM F.;ENSINGER CAROL L.;PETTER RUSSELL C.;DOWLING JAMES E.;KUMARAVEL GNANASAMBANDAM;CHANG HE XI;LIN KO CHUNG |
| 分类号 |
A61K31/675;A61K31/52;A61K31/522;A61K31/661;A61K31/662;A61P1/16;A61P3/00;A61P3/10;A61P7/10;A61P9/00;A61P9/02;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P11/16;A61P13/12;A61P17/02;A61P25/16;A61P25/24;A61P25/28;C07D453/02;C07D473/04;C07D473/06;C07D473/22;C07D493/08;C07D519/00;C07F9/6512;C07F9/6561 |
主分类号 |
A61K31/675 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
